The museum is named for the landscape painter, iconographer, and pedagogue, Giorgi Maisuradze. Born in Tsinandali, Telavi he was the first Georgian and the first person from the Caucasus to study at the St. Petersburg Imperial Academy of Arts. His works, the portraits of local nobility - Raphael Eristavi, Aleksandre, Nino and Ekaterine Chavchavadze, and Davit Dadiani – are kept in the Shalva Amiranashvili Museum of Fine Arts and the Zugdidi Museum. Only three of the icons he painted have survived to this day: the Face of the Lord, John the Apostle, and Lomisi St. George.
The museum itself is located in the former home of Prince Levan Jandieri. Jandieri was an active translator and journalist in the 1860s, and a close friend of Ilia Chavchavadze.
There are 4,972 objects kept within the museum, including a handwritten manuscript of The Knight in the Panther’s Skin from the 19th century, a charter from King Heraclius (Erekle) II, and archaeological materials unearthed around Kakheti, from weapons and work tools to women’s jewelry.